Bernard Fisher, a surgeon and clinical trialist who revolutionized the field of breast cancer research and all but eliminated reliance on disfiguring surgeries, died Oct. 16, 2019, at the age of 101.

At the time of his death, Fisher was the Distinguished Service Professor at the University of Pittsburgh School of Medicine.

“The world has lost a great man. Dr. Bernard Fisher, a courageous surgeon who almost single-handedly, over great resistance, changed the paradigm of breast cancer treatment from brutish to the more compassionate and successful treatment of today leading to reduction in mortality and morbidity,” Vincent DeVita, a former NCI Director and the Amy and Joseph Perella Professor of Medicine and Professor of Epidemiology and Public Health at the Yale School of Medicine, wrote on Facebook. “And I have lost a great friend. Rest well Bernie. There is a very large chorus of angels waiting for you.”