The widely publicized chemotherapy error that led to a journalist’s death in 1994 caused great sorrow among oncology nurses and catalyzed two decades’ worth of effort to improve patient safety. The situation taught oncology nurses, oncologists, and oncology pharmacists that interdisciplinary protocols and interprofessional communication are essential to preserving patients’ well-being. These patient safety efforts, along with parallel efforts to improve occupational safety in oncology, have made real progress in 20 years, but much remains to be done.