Now in its 10th year, the American Society of Clinical Oncology’s report, “Clinical Cancer Advances 2015: An Annual Report on Progress Against Cancer,” for the first time identifies ASCO’s Advance of the Year. Other new features in this special anniversary issue include: A Decade in Review, which recounts the biggest changes in cancer care since this report’s introduction; The 10-Year Horizon, which previews trends likely to shape the next decade of cancer care; and a special series of research, which highlights exciting new leads for treatment of rare cancers.

Advance of the Year: Gains in the Treatment of Chronic Lymphocytic Leukemia

In just over a year’s time, treatment for chronic lymphocytic leukemia (CLL), the most common form of adult leukemia, was transformed through the approval of four new therapy options. All the new treatments are easier to tolerate than prior therapies, making treatment possible for more patients than ever—especially elderly patients who account for the majority of patients with CLL and had urgently needed new, less toxic options.