This previously unavailable memoir by Charles Gordon Zubrod has been made available through the Cancer History Project by his family, with a foreword by Otis Brawley and Paul Goldberg.
Read the foreword here.
Zubrod served as head of the NCI Division of Cancer Treatment (appointed in 1956), NCI scientific director (1961-1974), Professor and chair of the department of oncology at the University of Miami School of Medicine and director of the Florida Comprehensive Cancer Center (1974-1990), and AACR President (1977-1978). He was also a Lasker Award recipient (1972).
Zubrod’s achievements include:
- Establishing the cancer clinical trials cooperative group system, beginning with the Acute Leukemia Group B, started with James Holland.
- Starting a program to recruit clinical associates to NCI.
- Establishing the NCI Leukemia Service and hiring two physicians with similar names, Emil (Tom) Frei III and Emil J Freireich, to run it and develop effective treatments for the disease.
- Developing quantitative methods that remain in use today in clinical trials and cancer treatment, including the phase I, II, and III system, endpoint measurements, the Zubrod scale, and flow sheets.
- Establishing NCI’s virus research program.
- Organizing and defending NCI’s drug development program.
The book was originally published privately and circulated to friends and family. It has been reproduced below as a scanned PDF, with a new foreword.